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Shazeed Karim

As seen in: BioRxiv
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Articles

Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.

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By Malay Mondal, Windfield Swetman, Shazeed Karim, Sabin Shrestha
| BioRxiv
Abstract Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increasingly observed in cells and serve as transient hubs for spatial organization and compartmentalization of biomolecules.
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Processing of Genomic RNAs by Dicer in Bat Cells Limits SARS-CoV-2 Replication

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By Iyanuoluwani Owolabi, Sergio Valdivia, Shazeed Karim, Sweta Khanal
| BioRxiv
Abstract Bats are reservoirs for numerous viruses that cause serious diseases in other animals and humans. Several mechanisms are proposed to contribute to the tolerance of bats to these pathogens. This study investigates the response of bat cells to double-stranded RNA generated by SARS-CoV-2 replication. Here, we found the involvement of Dicer in the processing of viral genomic RNAs during SARS-CoV-2 infection.
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