Shehbeel Arif on Muck Rack

Shehbeel Arif

As seen in: Nature, Frontiers in Immunology
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Articles

Multi-omics analysis of long COVID (post-COVID-19 condition) reveals persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation

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By Alexia Tasoula, Shehbeel Arif, Ethan Waisberg, Lucas Bauer, Elizabeth Aslinger, Joseph W. Guarnieri
| Frontiers in Immunology
Abstract Introduction: Post-COVID Syndrome (PCS), or long-COVID, is a major public health burden, but its underlying mechanisms remain poorly understood. Because acute SARS-CoV-2 infection induces marked suppression of mitochondrial oxidative phosphorylation (OXPHOS), we investigated whether persistent immunometabolic remodeling is a recurring transcriptional, metabolic, and proteomic feature of PCS.
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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs - Nature Communications

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By JangKeun Kim, Nídia S. Trovão, Keith Siew, Jiwoon Park, Eliah G. Overbey, Francisco J. Enguita, Victoria Zaksas, Cem Meydan, Stephen B. Baylin, Masafumi Muratani, Brett A. Kaufman, Marcelo A. Mori, Robert Schwartz, Diego Galeano, Christopher Mason, Lily Farmerie, Shehbeel Arif, D. Marshall Porterfield
| Nature Verified
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this work to determine the biological factors rescued by the countermeasure treatment.
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