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Shela Marie Algodon

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Articles

Striatal hyperechogenicity as an ultrasound imaging marker for prodromal X-linked dystonia-parkinsonism

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By Martje G. Pauly, Max Borsche, Henrike Hanssen, Uwe Walter, Dirk Dressler, Ana Westenberger, Christine A. Klein, Norbert Brüggemann, Cid Czarina E. Diesta, Paulo Cataniag, Jean Quint L. Oropilla, Shela Marie Algodon
| Nature Verified
Abstract X-linked dystonia-parkinsonism (XDP) is a neurodegenerative genetic disorder with striatal pathology. We investigated 138 participants (61 patients with XDP, 19 non-manifesting carriers (NMC), and 58 healthy controls (HC)) with transcranial sonography (TCS) to determine the hyperechogenicity of the lentiform nucleus (LN+), the size of the substantia nigra, and the width of the lateral and third ventricles. LN+ was correlated with LN volume as measured by structural T1 imaging.
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