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Shelby Winans

As seen in: Cell Press
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Articles by Shelby Winans

m5C Goes Viral

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By Shelby Winans, Johns Hopkins, Karen Beemon
| Cell Press Verified
In this issue of Cell Host & Microbe, Courtney et al. (2019a) Courtney D.G. Tsai K. Bogerd H.P. Kennedy E.M. Law B.A. Emery A. Swanstrom R. Holley C.L. Cullen B.R. Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression. Cell Host Microbe. 2019; 26 ( ) : 217-227 find that HIV-1 genomic RNA has much more m 5C than cellular mRNA. Deleting the m5C “writer” NSUN2 decreases HIV-1 m 5C levels, promotes translation of the HIV-1 5′ gag gene, and alters splicing at the A2 site.
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Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas

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By Johns Hopkins, Gary Lam, Shelby Winans, Sanandan Malhotra, PLOS Pathogens
| PLOS
Avian leukosis virus (ALV) is a simple retrovirus that causes a wide range of tumors in chickens, the most common of which are B-cell lymphomas. The viral genome integrates into the host genome and uses its strong promoter and enhancer sequences to alter the expression of nearby genes, frequently inducing tumors. In this study, we compare the preferences for ALV integration sites in cultured cells and in tumors, by analysis of over 87,000 unique integration sites.
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