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Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs
BBB blood-brain barrier BBBD blood-brain barrier dysfunction DCE dynamic contrast enhanced IE idiopathic epilepsy MMP9 matrix metalloproteinase 9 MRI magnetic resonance imaging SEA subtraction enhancement analysis 1 INTRODUCTION Epilepsy is the most common chronic neurological disease in dogs and humans.1, 2 Epileptogenesis can be primary or secondary to brain insults such as trauma, ischemia, neoplasia or inflammation.2-4 As in human patients, 20% to 30% of epileptic dogs are resistant to...
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