Shenao Zhou on Muck Rack

Shenao Zhou

As seen in: Nature
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Articles

RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production

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By Yu Yang, YUE WANG, Yang Wang, Erpeng Wu, Hao Chen, Liming Sun, Chi Zhang, Shuhui Cao, Jingwen Li, Huiping Qiang, Lincheng Zhang, Yuqing Lou, Rong Qiao, Yan Zhou, Runbo Zhong, Hua Zhong, Shenao Zhou
| Nature Verified
Abstract Receptor-interacting protein kinase 3 (RIPK3) has emerged as a central player in necroptosis and apoptosis activation in specific scenarios, concurrently modulating inflammatory responses. Here, we reveal that direct activation of RIPK3 concomitantly triggers mixed lineage kinase domain-like (MLKL) phosphorylation, caspase activation, and gasdermin cleavage within individual cells, inducing PANoptotic cell death.
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