Shengfang Wang

Abstract Adenine base editors (ABEs) are powerful tools for gene therapy. However, efficient version of ABEs (e.g. ABE8e) always induce excessive bystander and off-target editing events and are large in size, hindering their potential in clinical disease treatment. Here, we develop a pre-trained Protein-Nucleic Acid Constrained Language Model to design ABE8e with high activity, reduced editing window and decreased size.

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ejss70169-sup-0001-Supinfo.docWord document, 2.5 MB Data S1: Supporting Information. References , and . 2024. “ Glomalin and Carbon Sequestration in Terrestrial Ecosystems.” In Arbuscular Mycorrhizal Fungi and Higher Plants: Fundamentals and Applications, edited by G. J. Ahammed and R. Hajiboland, 239–258. Springer Nature Singapore. , , , , , and . 2018.

Back to Journals » Journal of Inflammation Research » Volume 18 Authors Wang S, Wang H, Huang Y, Zhu J, Cheng Q, Gao C Received 10 June 2025 Accepted for publication 8 October 2025 Published 31 October 2025 Volume 2025:18 Pages 15153—15164 DOI https://doi.org/10.2147/JIR.S545890 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Durga Prasanna Misra Shengfang Wang,1– 3,* Hao Wang,4,* Yanqing Huang,5,*...