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Shengli-Li Ming on Muck Rack

Shengli-Li Ming

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Articles

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

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By Jia-ming Yang, Shengli-Li Ming, Meng-Hua Du
| eLife
eLife Assessment This valuable study presents convincing data demonstrating that alpha herpesvirus triggers nuclear export of HDACs, which are then degraded in an MDM2-dependent manner. This virus-driven process leads to histone hyperacetylation and activation of the DNA damage response, which promotes viral replication.
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