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Matched tissue-blood whole-exome sequencing improves detection of genetic etiologies in pediatric drug-resistant epilepsy
1 Introduction Epilepsy is a common chronic neurological disorder affecting approximately 1% of the global population, characterized by recurrent, transient disruptions of neurological function caused by abnormal neuronal discharges (1, 2). Despite the increasing availability of antiseizure medications (ASMs) in recent years, approximately 20%–40% of pediatric patients still respond poorly to existing therapies and develop drug-resistant epilepsy (DRE) (3–5).
Predictive Laboratory Markers for Gastrointestinal Complications in Ch
Qin Guo,1,* Shengying Xia,2,* Yan Ding,3 Fan Liu3 1Department of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, People’s Republic of China; 2Department of Emergency and Critical Care Center, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430016, People’s Republic of China; 3Department of Rheumatology and Immunology, Wuhan Children’s Hospital, Tongji...
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