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Shensen Li

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Articles

Integrins in the kidney — beyond the matrix - Nature Reviews Nephrology

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By Fabian Bock, Shensen Li
| Nature Verified
Abstract The development and proper functioning of the kidney is dependent on the interaction of kidney cells with the surrounding extracellular matrix (ECM). These interactions are mediated by heterodimeric membrane-bound receptors called integrins, which bind to the ECM via their extracellular domain and via their cytoplasmic tail to intracellular adaptor proteins, to assemble large macromolecular adhesion complexes.
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