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Shenzhen Metabolism

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Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

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By Zhendong Zhu, Targeted Imaging, Tlr Ligands, Shenzhen Metabolism
| Wiley Online Library Verified
1 Introduction Low-grade chronic inflammation associated with aging, termed inflammaging, is one of the crucial hallmarks of mammalian aging [1, 2]. Tissue-resident macrophages (TRMs) play essential roles in maintaining innate immune balance and tissue homeostasis [3, 4]. In the testes, an immune-privileged organ, minimizing inflammatory responses is crucial for normal testicular function [5].
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