Shephali Milind Kadam on Muck Rack

Shephali Milind Kadam

As seen in: Nature
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Articles

Establishment and functional analysis of an inducible Apoc2- knockout mouse model to investigate the role of Apoc2 in normal hematopoiesis

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By Xiaochen Zhang, Mateusz Pospiech, Yiyu Xiao, Denis Sviridov, Anna Wolska, Alan T Remaley, Houda Alachkar, Ritu Chandwani, Kanaka Dhuri, Atham Ali, Bhakti Thakker, Shephali Milind Kadam, Wenda Zhu
| Nature Verified
Abstract Apolipoprotein C2 (APOC2) has been identified as a potential therapeutic target for acute myeloid leukemia, but its impact on normal hematopoiesis remains unclear. Here we generated a global inducible Apoc2 knockout (KO) mouse model by breeding R26-CreERT2 mice with mice homozygous for Apoc2 lox sites (Apoc2fl/fl) over three generations. Global Apoc2 KO was induced in 4–8-week-old mice by 5 consecutive days of intraperitoneal administration of tamoxifen.
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