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Shibojyoti Lahiri on Muck Rack

Shibojyoti Lahiri

As seen in: Nature, BioRxiv
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Articles

Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins

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By Priyanka Bansal, Shibojyoti Lahiri, Chandni Kumar, Lorenz Spechtenhauser, Lorenzo Galanti, Erika Chacin, Marisa Müller, Petra Vizjak, Tobias Straub, Felix Mueller-Planitz, Johannes Stigler, Andrés Aguilera, Belén Gómez-González, Boris Pfander, Philipp Korber, Axel Imhof, Christoph F. Kurat, Jessica Furtmeier, Garp Linder, María Ángeles Ortíz-Bazán
| Nature Verified
Abstract The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role during S phase. It phosphorylates the replicative helicase (minichromosome maintenance, MCM complex), which leads to the initiation of replication. However, few other targets, besides the MCM complex, are known, leaving DDK an understudied kinase. Here, we determine the nuclear DDK-dependent phosphoproteome by a two-pronged mass spectrometry approach.
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Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

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By Christoph F. Kurat, Priyanka Bansal, Chandni Kumar, Shibojyoti Lahiri
| BioRxiv
Abstract The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role in the nucleus during S phase, where it directly phosphorylates the replicative helicase, the minichromosome maintenance (MCM) complex. This leads to the initiation of chromosome replication. However, aside from the MCM complex, few other targets have been identified to date, leaving DDK an understudied kinase.
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