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Articles by Shida Chen
Longitudinal Trajectories of 3-Dimensional Eye Shape and Pathological Sequelae in High Myopia
Key Points Question Are longitudinal 3-dimensional (3D) globe remodeling trajectories on magnetic resonance imaging (MRI) associated with structural and functional outcomes independent of axial elongation in highly myopic eyes? Findings In this cohort study of 30 participants (60 eyes), 3D MRI identified 5 remodeling trajectories associated with baseline age and globe geometry.
CD36-mediated lipid-accumulation in reactive microglia contributes to retinal degeneration via the NLRP3-IL-1β pathway in mice
Abstract Microglia are central regulators of retinal immune homeostasis, yet their pathogenic states in retinal degeneration remain less well understood. Here we identified a distinct subset of lipid-accumulated reactive microglia (aLARM), using scRNA sequencing and spatial transcriptomics in NaIO3-induced retinal degeneration mice, predominantly localized to the outer retina. aLARM were conserved across mouse models and patients and uniquely marked by high CD36 expression.
Thyroid autoimmunity, thyroid function, and endometriosis: reproductive immune-endocrine crosstalk and causal uncertainty
Abstract Background: Endometriosis is an estrogen-dependent inflammatory disorder associated with pelvic pain, infertility, repeated treatment, and impaired quality of life. Thyroid dysfunction and thyroid autoimmunity are also common in reproductive-aged women and may affect menstrual cyclicity, ovarian function, implantation, pregnancy maintenance, and assisted reproduction.
Pathologic Myopia Globe Shape and Long-Term Prognosis
Pathologic Myopia Globe Shape and Long-Term Prognosis Key Points Question Do baseline 3-dimensional (3D) eye shape subtypes defined by magnetic resonance imaging (MRI) predict 15-year structural and functional prognosis in highly myopic eyes? Findings In this cohort study, 6 distinct prognostic trajectories were identified, delineating a morphologic map of the natural history of high myopia.
Primary aldosteronism beyond laterality: integrating subtype assignment with outcome-oriented risk stratification
Abstract Primary aldosteronism (PA) has traditionally been approached as a disorder of anatomical subtype classification, with treatment decisions largely structured around distinction between unilateral and bilateral disease. Although this framework remains essential for therapeutic orientation, it does not fully account for the marked heterogeneity in cardiovascular, renal, and metabolic outcomes observed across patients with PA.
Type 5 diabetes mellitus: nutritional-imprinted β-cell insufficiency, diagnostic gaps, and emerging therapeutic strategies
Abstract Historical descriptions of malnutrition-related diabetes mellitus (MRDM) have regained attention in contemporary discourse, with the term type 5 diabetes mellitus (T5DM) increasingly used as a harmonized research construct to describe insulin-deficient diabetes associated with early-life undernutrition.
Dynamic Mechanical Behaviour and Energy Evolution of Coal Measure Sandstone and Implications for Coalbed Methane Development
1 Introduction As a significant unconventional natural gas resource, the efficient development of coalbed methane (CBM) holds critical strategic importance for optimising energy structure, ensuring energy security and facilitating low-carbon transition (Tao, Chen, and Pan 2019; Tao, Pan, et al. 2019; Liu et al. 2022; Akimbekov et al. 2024; Gao et al. 2024; Khajooie et al. 2024; Li, Zhang, et al. 2024; Zhao et al. 2025).
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy - Nature Communications
Elemental Geochemical Characteristics and Organic Matter Enrichment Model of Marine-Continental Transitional Shale in Longtan Formation, Southern Sichuan Basin | ACS Omega
Cite Jump to ExpandCollapse ArticleAugust 23, 2025 Elemental Geochemical Characteristics and Organic Matter Enrichment Model of Marine–Continental Transitional Shale in Longtan Formation, Southern Sichuan Basin Click to copy article linkArticle link copied! Wei Gao Wei Gao College of Resources and Environmental Engineering, Guizhou University, Guiyang 550025, China Guizhou Provincial Engineering and Technology Research Center of Coalbed Methane and Shale Gas, Guizhou Provincial Coalfield...
Comparative efficacy of different functional hydrogel dressings in healing diabetic foot ulcer: A systematic review and network meta‐analysis
Aims Functional hydrogel dressings offer a promising therapeutic approach, and optimizing their formulations is crucial for improving diabetic foot ulcers (DFUs) outcomes. This study explores the comparative efficacy of different functional hydrogel dressings in DFUs treatment. Materials and Methods We conducted a systematic review and Bayesian network meta-analysis of randomized controlled trials evaluating functional hydrogel dressings for DFUs treatment.
Optimising Neural Networks for Enhanced Fracture Density Prediction in Surrounding Rock of Coalbed Methane Reservoir
Conflicts of Interest The authors declare no conflicts of interest. References , , , and . 2019. “Evaluation of New Method for Estimation of Fracture Parameters Using Conventional Petrophysical Logs and ANFIS in the Carbonate Heterogeneous Reservoirs.” Journal of Petroleum Science and Engineering 172: 1092–1102. 2010. “Effect of Fracture Dip and Fracture Tortuosity on Petrophysical Evaluation of Naturally Fractured Reservoirs.” Journal of Canadian Petroleum Technology 49, no. 9: 69–76. , , , , , and .
Energies | Free Full-Text | Impacts and Countermeasures of Present-Day Stress State and Geological Conditions on Coal Reservoir Development in Shizhuang South Block, Qinshui Basin
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Safety of Repeated Low-Level Red-Light Therapy for Myopia: A Systematic Review
The authors have declared no competing interest. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024516676 This research was funded by the National Natural Science Foundation of China (82371086). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Geological and Geochemical Responses to Productivity of CBM Wells in the Baiyang River Block of the Southern Junggar Basin, China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Frontiers | Enhancing surgical precision and efficiency: a study and comparison of a three-dimensional surgical video system in proliferative diabetic retinopathy surgery
1. Introduction Proliferative diabetic retinopathy (PDR), a severe threat to vision, affects ~6.96% of patients with diabetes globally, making it the leading cause of blindness in the working-age population (1–3). PDR is characterized by the formation of neovascularized and proliferative membranes, which can lead to vitreous hemorrhage, tractional retinal detachment, neovascular glaucoma, and other serious consequences (4–6).
Sex differences in the relationship between axial length and dry eye in elderly patients
Masahiko Ayaki1,2*, Hidemasa Torii1, Erisa Yotsukura1 and Kazuno Negishi1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan 2Otake Eye Clinic, Kanagawa, Japan Purpose: The aim of this study was to explore the association between myopia and dry eye (DE)-related ocular parameters. Methods: We recruited a total of 460 patients (mean age, 73.6 years; 40.2% men) and performed DE-related, axial length (AL) and retinal examinations.
Zheng Li - OCT News
Enhanced depth imaging-optical coherence tomography of the choroid in moderate and severe primary angle-closure glaucoma | Ophthalmology | Sun Yat-Sen University Purpose To compare the choroidal thickness (CT) in eyes with moderate and severe primary angle-closure glaucoma (PACG) with the eyes of healthy controls. Methods Fifty-nine patients (59 eyes) with PACG and 56 age-matched normal subjects underwent macular CT scanning using enhanced depth imaging–optical coherence tomography.
Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change
Purpose To develop a classification system of visual field (VF) abnormalities in highly myopic eyes with and without glaucoma. Design Secondary analysis of VF data from a longitudinal cohort study. Participants One thousand eight hundred ninety-three VF tests from 1302 eyes (825 individuals). Methods All participants underwent VF testing (Humphrey 24-2 Swedish interactive threshold algorithm standard program; Carl Zeiss Meditec) and detailed ophthalmic examination.
Coal Reservoir Heterogeneity in Multicoal Seams of the Panguan Syncline, Western Guizhou, China: Implication for the Development of Superposed CBM-Bearing Systems
The reservoir heterogeneity of multiple coal seams in the Panguan area was systematically analyzed based on coalmine geological exploration data, field-test data, and laboratory tests.
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