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Shigeta Tashiro

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Articles

Legumain-Mediated Activation of PAR2 Contributes to Mechanical Hypersensitivity in a Rat Model of Tongue Cancer

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By Suzuro Hitomi, Yoshinori Hayashi, Shigeta Tashiro
| Wiley Online Library Verified
1 Introduction Oral cancer is the sixth most common cancer worldwide (Shah and Gil 2009). According to 2020 statistics, the number of new cases of lip and oral cancer is approximately 400,000, and the number of new deaths is approximately 200,000 (Chai et al. 2020). Squamous cell carcinoma (SCC) incidence has increased in various regions of the world (Ng et al. 2017). Patients with oral cancer rate pain as the worst symptom (Connelly and Schmidt 2004). Pain intensity worsens as oral cancer progresses.
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