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1 INTRODUCTION It is well known that the epididymis of each species has a subtly different anatomy and physiology, though all are adapted to ensure effective sperm maturation and reproductive success.1 Many insights on epididymis function come from rodents and larger mammals such as the pig2-9 which are particularly well studied but may not accurately represent the human organ.
Abstract A complex network of transcription factors regulates genes involved in establishing and maintaining key biological properties of the human airway epithelium. However, detailed knowledge of the contributing factors is incomplete. Here we characterize the role of Krüppel-Like Factor 5 (KLF5), in controlling essential pathways of epithelial cell identity and function in the human lung.
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