Shihoko Kojima

Abstract Flavonoids are an abundant specialized metabolite produced by plants for a range of functions, including pigmentation, hormonal signaling, UV protection, and drought tolerance. We previously showed that flavonoids also influence the circadian clock in Arabidopsis. Here, we report that the antioxidant properties of dihydroxy B-ring flavonoids is responsible for regulating the amplitude of the core clock gene luciferase reporter, TOC1:LUC.

Abstract Antisense transcripts are a unique group of non-coding RNAs and play regulatory roles in a variety of biological processes, including circadian rhythms. Per2AS is an antisense transcript to the sense core clock gene Period2 (Per2) in mouse and its expression is rhythmic and antiphasic to Per2. To understand the impact of Per2AS-Per2 interaction, we developed a new mathematical model that mechanistically described the mutually repressive relationship between Per2 and Per2AS.