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Shiquan Liang

As seen in: Nature
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Articles

Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression

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By Meifang Pan, Mengling Jiang, Jianping Cui, Jun Zhang, Yaping Wang, Jingrong Shi, Rui Li, Wei Zhang, Liqiang Feng, Haisheng Yu, Yi-Ping Li, Fengyu Hu, Xiaoping Tang, Hongbo Guo, Feng LI, Qinghong Fan, Chengqian Feng, Shiquan Liang
| Nature Verified
Abstract Interferon (IFN) pathways form the innate barrier against viral invasion and partial deficiency in these pathways allows human virus infection. Whether a complete IFN pathway deficiency could confer the susceptibility to human viral infection independent of expressing the human viral receptor remains unknown. We develop an innate immunity severely deficient mouse model, designated AGL, which features one-step knock-out of the IFNAR, IFNGR and IFNLR.
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