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Shiuan Nee Goh on Muck Rack

Shiuan Nee Goh

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Articles

Quantitative RNA modification mapping by mass spectrometry with isobaric tags and nucleobase fragment analysis

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By Junzhou Wu, Jingjing Sun, Yifeng Yuan, Valérie de Crécy-Lagard, Peter C. Dedon, Shiuan Nee Goh, Hazel Chay
| Nature Verified
Abstract RNA modifications regulate RNA stability, translation, stress responses, and disease processes, yet their function remains poorly understood due to technical limitations in sequence analysis. Here, we present an RNA-specific isobaric tandem mass tagging (RMT) platform for omic-scale quantitative mapping of RNA modifications. The platform combines RNA-specific tags adapted from proteomics with an end-to-end workflow spanning sample preparation through data processing.
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