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Shizi Tan on Muck Rack

Shizi Tan

As seen in: Nature
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Articles

EGCG inhibits gastric cancer HGC27 cells invasion and migration by targeting the Hedgehog signaling pathway

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By Shuai Chen, Kan Zhou, Zhuo Liu, Mengqi Wu, Pingping Cheng, Shaohua YANG, Jianhong Luo, Zhuo He, Hongyu Deng, Mingjing Peng, Mengyu Wan, Songqing Tang, Chaohui Zuo, Shizi Tan
| Nature Verified
Abstract Gastric cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for effective and low-toxic therapeutic alternatives. This study investigated the antitumor efficacy of Epigallocatechin gallate (EGCG) in gastric cancer, focusing on the Hedgehog signaling pathway. In HGC27 cells, EGCG treatment inhibited proliferation, colony formation, migration, and invasion in a dose- and time-dependent manner.
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