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Shraddha Bonkar Dethe on Muck Rack

Shraddha Bonkar Dethe

As seen in: Nature
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Articles

Phase II Non-Randomised Trial of Oral Chlorophyllin in Haemorrhagic Cystitis from Radiation Therapy (CLARITY Trial): clinical and quality-of-life outcomes with exploratory proteomics

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By Gagan Prakash, Vikram Gota, Deepak Sharma, Supriya Chopra, Mahendra Pal, Amandeep Singh Arora, Ramya Nagarajan, Ankit Misra, Ganesh Bakshi, Vedang Murthy, Priyamvada Maitre, Lavanya Gurram, Prachi Mittal, Rahul Checker, Mahendra Joshi, Shivkumar Madki, Saurabh Gupta Verified, Sharath Kumar, Santosh Menon, Tapan K. Ghanty, Sadhana Kannan, Rajendra A. Badwe, Pankaj Chaturvedi, Sudeep Gupta, Santosh K Sandur, Raghavendra S. Patwardhan, Shraddha Bonkar Dethe, Priyal Gawad, Sanjana Ghadge
| Nature Verified
Abstract Chronic Haemorrhagic Cystitis (cHC) affects 5–15% of patients after pelvic radiotherapy. Sodium-copper-chlorophyllin, a semi-synthetic chlorophyll derivative, has shown promise in preclinical models. The phase II CLARITY trial evaluated oral chlorophyllin for radiation-induced cHC. This prospective, single-centre, single-arm phase II trial (NCT05348239) enrolled adults with grade 2–4 haematuria persisting ≥ 3 months after pelvic radiotherapy.
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