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Shreyasee V. Kumbhar on Muck Rack

Shreyasee V. Kumbhar

As seen in: Nature
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Articles

Oncogenic Kras targeting with MRTX1133 or Daraxonrasib specifically synergize with anti-CTLA4 to promote anti-tumor immunity in pancreatic cancer

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By Krishnan K Mahadevan, Ana Maldonado, Bingrui Li, Aaron A Bickert, Sujan Piya, Amari M. Sockwell, Kent Arian, Hikaru Sugimoto, Shabnam Shalapour, David Hong, Timothy Heffernan, Anirban Maitra, Raghu Kalluri, Adrian Kacperczyk-Perdyan, Shreyasee V. Kumbhar, Sami J. Morse
| Nature Verified
Abstract Lack of sustained response to oncogenic Kras (Kras*) inhibition in pancreatic ductal adenocarcinoma (PDAC) underscores the need to identify effective combination therapies. Here, we demonstrate that Kras* targeting using MRTX1133 or Daraxonrasib recruits diverse T-cell infiltrates, including regulatory (Tregs), effector and exhausted T cells into the PDAC microenvironment.
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