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Shu-Ying Bie on Muck Rack

Shu-Ying Bie

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Articles

A cuproptosis-inducing covalent organic framework synergizes with oncolytic virus for tumor radiotherapy

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By Yuan-Tong Liu, Shuo Wang, Xiang-Bo Wan, Liang Zhang, Ke-Shan Liu, Shu-Ying Bie, Ying-Qi Wei, Shan-Shan Gou, Xing-Zhen Li
| Nature Verified
Abstract Acquired radioresistance limits effective radiotherapy. Cuproptosis is a copper-dependent form of cell death driven by mitochondrial copper accumulation and lipoylated protein aggregation. Building on evidence that radioresistant cancer cells exhibit increased cuproptosis susceptibility, here we combine a radiation-responsive, copper-incorporated covalent organic framework (COF‑Tpy‑Se‑Cu) with an oncolytic adenovirus to target this vulnerability.
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