Shuai Ying

1 Introduction Glioma tumors are the most common primary malignant tumors of the central nervous system and are associated with poor outcomes [1]. Glioblastoma (GBM), the most aggressive subtype of glioma, accounts for approximately half of all glioma cases [2]. The current standard of care for GBM patients involves radiotherapy in combination with temozolomide (TMZ), which increases median survival from 12.1 to 14.6 months [3, 4].

1 Introduction Neuropathic pain is a complex condition that results from damage or dysfunction within the somatosensory nervous system. It affects about 7–10% of people globally and is particularly common among middle-aged individuals and women (van Hecke et al., 2014). There are two main types of neuropathic pain based on the underlying cause: central and peripheral.