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Articles

Real world pharmacovigilance study of FDA adverse event reporting system events for Spiriva Respimat

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By Kai Chen, shuang zhao, Weiye Deng, Qingrong Ma, Haiping Xiao
| Frontiers
Abstract Background: Spiriva Respimat (tiotropium bromide) is a first-line therapy for chronic obstructive pulmonary disease (COPD) and asthma, prescribed to millions worldwide. However, its comprehensive real-world safety profile, particularly rare and late-onset adverse events, remains incompletely characterized in clinical practice.
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Activation of GLP-1R ameliorates alcohol withdrawal induced anxiety-like behavior by regulating neuronal mitochondrial quality control

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By Ziqi Wang, Wei Zhao, Xiaofei Chen, shuang zhao, Xiaotong Li, Quanwei Yang, Hanting Zhang, Fangjiao Zong
| Frontiers
Abstract Introduction: Alcohol use disorder (AUD) is a specific psychological state induced by repeated heavy drinking, and withdrawal symptoms such as anxiety are closely related to relapse after withdrawal. While neuronal damage caused by alcohol is considered a significant precipitating factor for withdrawal-induced anxiety, the underlying molecular mechanisms remain unclear.
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Measurement and improvement strategies of “quantity-quality-flow” comprehensive carrying capacity in the metropolitan fringe: a case of Shunyi District in Beijing, China

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By Wenying Peng, shuang zhao, Zeyu Chen, Ziyi Shan
| Nature Verified
Abstract The comprehensive urban carrying capacity is related to sustainable urban development, and it affects urban planning and design. Metropolitan fringe is the main area for urban spatial expansion, characterized by frequent factor flow and complex urban-rural relationships. Its comprehensive carrying capacity research is of great significance.
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