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Shuanggong Liu

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Articles

CREG1 Attenuates Osteoarthritis Progression by Suppressing Chondrocyte Pyroptosis Through the PINK1/Parkin‐Mediated Mitophagy Pathway

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By Xianming Fei, Shuanggong Liu, Guangxu Song
| Wiley Online Library Verified
Background Osteoarthritis (OA) is a progressive degenerative disorder driven by complex pathogenic mechanisms. Increasing evidence indicates that NLRP3 inflammasome–mediated chondrocyte pyroptosis contributes critically to OA progression. Cellular repressor of E1A-stimulated gene 1 (CREG1), a secreted glycoprotein involved in cellular homeostasis and lysosomal function, has not been well characterized in OA.
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