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Shuilan Yao

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Articles

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

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By Yun Liang, Xinwen Liang, Shuilan Yao
| Wiley Online Library Verified
CRC Colorectal cancer Kla Lysine lactylation LDH Lactate dehydrogenase MCT Monocarboxylate transporter 1 Introduction Colorectal cancer (CRC) ranks among the world's most prevalent malignancies. Epidemiological data from 2022 indicate over 1.9 million new cases, ranking second in cancer-related mortality worldwide [1]. By 2030, the global burden of CRC is projected to rise by 60%, with an estimated 2.2 million new cases and up to 1.1 million deaths [2].
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