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ShukChing Chong

As seen in: Frontiers
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Articles

Correlation of UGT1A1 genotypes with newborn hyperbilirubinemia using newborn genetic screening

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By Wen Zeng, Xiaoou Li, Jianjiang Zhu, Qianyong Ji, ShukChing Chong
| Frontiers
Abstract Background: This study evaluated whether uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) variants identified through newborn genetic screening are associated with the development of clinically significant neonatal hyperbilirubinemia. Methods: Next-generation sequencing (NGS) was performed in 1,019 newborns, and pathogenic (P)/likely pathogenic (LP) UGT1A1 findings were confirmed by Sanger sequencing.
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