Shuken Boku

Abstract We investigated cerebrospinal fluid (CSF) ethanolamine (EA) levels in major depressive disorder (MDD), to validate our previous findings on EA (Ogawa et al., 2015) and broaden its biological context and translational relevance. Using human samples (sets A–C) and animal models, we explored the implications for replication, translational potential, therapeutic development, and mechanistic insight.

The cellular steps through which 22q11.2 hemizygous deletions cause social and cognitive deficits are still poorly understood. This study focused on Tbx1, one of the genes encoded in 22q11.2.

This is the first study to investigate TL and mtDNAcn in post-mortem blood and brain samples of suicide completers. First, we found significantly shorter TL and higher mtDNAcn in blood samples from suicide completers, which remained significant after excluding subjects with psychiatric disorders and/or psychotropic medication use. Our results were similar to prior findings of shortened TL and increased mtDNAcn in cohorts with MDD or other neuropsychiatric conditions30, 31.