Shunhai Wang on Muck Rack

Shunhai Wang

Tarrytown
As seen in: Nature, ACS Publications
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Articles

Comprehensive forced degradation study revealing diverse chemical and physical degradation pathways of AAV8 - Gene Therapy

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By Kuan-Yu Lai, Song Nie, Timothy N. Tiambeng, Shuli Tang, Yu Huang, Yuetian Yan, Shashwat Mishra, Aynur Hermann, Nina Jiabao Liu, Ning Li, Mohammed Shameem, Shunhai Wang, Li Hua Zhi, Yu-Chieh Ariel Chen, Humam Al-Rubaye, Michael Rosconi, Dingjiang Liu
| Nature Verified
Abstract While recombinant adeno-associated virus (AAV) holds significant promise for effective and durable gene delivery for gene therapy, a thorough understanding of the critical quality attributes (CQAs) along with the degradation pathways of AAV under the various stresses that may occur during manufacturing, storage, and handling remains limited.
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Development of a Flow Through-Based Limited Digestion Approach for High-Throughput and High-Sequence Coverage Mapping of Therapeutic mRNAs

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By Shuli Tang, Gao-Yuan Liu, Yuetian Yan, Shunhai Wang
| dx.doi.org
Since their discovery in the 1960s, (1) messenger RNAs (mRNAs) have been a target of interest as therapeutic tools by researchers. (2,3) Early investigation of mRNA-based therapeutics dates back to the late 1990s (4) but was fraught with challenges related to the stability, cell delivery efficiency, and the induced immune responses of the mRNA molecules.
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Discovery and Characterization of an Acid-Labile Serine-Lysine Cross-Link in Antibody High-Molecular-Weight Species Using a Multipronged Mass Spectrometry Approach

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By Gao-Yuan Liu, Zhengqi Zhang, Yuetian Yan, Shunhai Wang
| ACS Publications
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem.
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