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Shuntian Zou

As seen in: Frontiers in Immunology
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Articles

P62 in colorectal cancer: from inflammation suppression to cancer promotion

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By Jianlin Huang, Lin Liu, Hui Chen, Jiaxin Chen, Yuxuan Pang, Xu Wu, Minghua Liu, Shuntian Zou
| Frontiers in Immunology
Abstract The autophagy adaptor and scaffold protein p62 plays a critical role in colorectal cancer (CRC) progression. As a malignancy driven by chronic inflammation, CRC arises from the combined effects of oncogenic signaling activation, genetic mutations, and epithelial barrier disruption. During early stages of inflammation, p62 exerts tumor-suppressive functions by clearing inflammasomes, activating NRF2, and downregulating inflammatory cytokines.
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