Skip To Main Content
Shuojie Huang on Muck Rack

Shuojie Huang

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Shuojie

Contact Shuojie, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Microbiota-based modulation of intratumoral cholesterol metabolism for colorectal cancer treatment

|
By Jiayan Wu, Liguo Li, Yingyao Lai, Jinming Li, Pallavi Asthana, Lixiang ZHAI, Lexin Chen, Baisen Chen, Yijing Zhang, Lin Lu, Weihong Kuang, Hui Shi, Yuanyuan Luo, Xiangxin Kong, Kui Ming Chan, Shuofeng Yuan, Xia Yuan, Weizhen Huang, Yongdui Ruan, Hongmei Lu, Ya Su, Mohamad Koohi-Moghadam, Aiping Lyu, Zhaoxiang Bian, Yixing Ren, Xianjing Hu, Yanlei Ma, Minting Chen, Susma Gurung, Jin Lyu, Shuojie Huang, Zhanping Gou
| Nature Verified
Abstract Excess cholesterol accumulates in colorectal cancer (CRC) and promotes its progression, yet systemic cholesterol-lowering has limited benefits and safety concerns. Here we show that redirecting intestinal cholesterol metabolism through the gut microbiota generates a metabolite, 4-cholesten-3-one (4-C-3), which suppresses CRC growth. A screen of microbial cholesterol metabolites showed that 4-C-3 is depleted in faecal and tumour samples from patients with CRC.
Open in Who Shared Issue with article?
See all 1 articles