Shusaku Mizukami on Muck Rack

Shusaku Mizukami

As seen in: Nature
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Articles

Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library

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By Asahi Hirata, Toshihiro Suzuki, Aiko Teshima, Awet Alem Teklemichael, Momoko Akimoto, Mayumi Taniguchi, Rukman Muslimin, Sho Ogaki, Alimuddin Ali, Shusaku Mizukami, Kenji Arakawa
| Nature
Abstract Our group explores the antimalarial compounds from the Streptomyces culture library. Pilot screening showed significant antimalarial activity in Streptomyces antibioticus HUT6035 (synonym of strain NBRC3117). We here isolated antimalarial compounds through large-scale fermentation and subsequent purification using chromatographies. Strain HUT6035 accumulated actinomycins X2 and X0ß, which were 4-oxo and 4-hydroxy proline derivatives of actinomycin D, respectively.
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