Shuying Wu
As seen in:
Nature,
Wiley Online Library,
Frontiers,
MDPI,
ACS Publications,
Royal Society of Chemistry
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Deer velvet antler peptides protect premature ovarian insufficiency by modulating CHK2-TAp63α signaling and gut microbiota
Abstract Premature ovarian insufficiency (POI) is a prevalent complication among childhood, adolescent, and young adult (CAYA) cancer survivors, yet lacks effective treatments. Here we show that therapeutic gavage of deer velvet antler peptides (DVAP) reversed the reduction of primordial follicles (PFs), enhanced fertility, and suppressed apoptosis in cyclophosphamide (CTX)-induced POI mice by modulating the gut microbiota and the CHK2-TAp63α signaling pathway.
Dynamic neuronal ensembles encode burst-suppression revealed by cortex-wide optical-electrical interfaces
Abstract Burst suppression is widely observed across cortical regions during reversible or pathological unconsciousness, yet its neuronal organization remains incompletely understood. Here we present an integrated Cortex-wide Optical-electrical Dual-modal Explorer (CODE) system to examine neuronal dynamics during burst suppression under isoflurane anesthesia in the mouse.
Triboelectric Wearable Devices for Wound Healing: Materials, Mechanisms, and Innovative Designs
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The authors have nothing to report. References 1, , , et al., “Polysaccharide-Based Nanogels to Overcome Mucus, Skin, Cornea, and Blood-Brain Barriers: A Review,” Pharmaceutics 15 (2023): 2508, https://doi.org/10.3390/pharmaceutics15102508.
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