Shyl Lamba on Muck Rack

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Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity

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By Alex Chialastri, Saumya Sarkar, Elizabeth E. Schauer, Shyl Lamba
| biorxiv.org
New Results doi: https://doi.org/10.1101/2023.05.06.539708 Abstract Transmission of 5-methylcytosine (5mC) from one cell generation to the next plays a key role in regulating cellular identity in mammalian development and diseases. While recent work has shown that the activity of DNMT1, the protein responsible for the stable inheritance of 5mC from mother to daughter cells, is imprecise; it remains unclear how the fidelity of DNMT1 is tuned in different genomic and cell state contexts.
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