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Shyue Leh Chen on Muck Rack

Shyue Leh Chen

As seen in: Nature, MDPI
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Articles

Analysis of heterocycle formation and stereochemical control by a non-ribosomal peptide synthetase condensation domain

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By Wei Cao, Jialiang Wang, Shyue Leh Chen, Dandan Li, Xiaozheng Wang, Zixin Deng, Jingdan Liang, Zhijun Wang
| Nature Verified
Abstract Non-ribosomal peptide synthetases (NRPSs) produce diverse bioactive peptides, including antibiotics and antitumour agents, by integrating proteinogenic and non-proteinogenic amino acids alongside tailoring modifications, such as epimerization (E) and cyclization. Here we demonstrate that the tetrahydropyrimidine ring of pyoverdine is synthesized by the condensation (C) domain PvdL-C3, revealing cyclization capability of a canonical NRPS domain.
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In-Situ Purification of Non-Ribosomal Peptide Synthetases Assembly Line for Structural and Biochemical Studies

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By Wei Cao, Jialiang Wang, Shyue Leh Chen, Suen Kit Wu
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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