Si-ying He
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Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction
1 Introduction Bone infection (osteomyelitis) continues to present a substantial and costly challenge within orthopedics. This condition is defined by sustained microbial colonization, biofilm formation, chronic inflammation, and a hostile microenvironment that collectively impede bone regeneration [1].
Melatonin, a potentially effective drug for the treatment of infected bone nonunion
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jpi12914-sup-0001-Appendix.docx15.3 KB Supporting information. jpi12914-sup-0002-Supplementary_Figure_1.tif2.7 MB Supplementary Figure 1. CCK8 was used to detect the cell viability of osteoblasts treated with different concentrations of melatonin with/without Luz. n = 3/group, ***P < .001 vs. group Infected. jpi12914-sup-0003-Supplementary_Figure_2.tif3.4 MB Supplementary Figure 2.
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