Si-Ying Wang

Abstract Regulation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) function has emerged as a novel strategy for major depressive disorder (MDD); however, the underlying molecular mechanisms remain unclear.

1 Introduction Chronic periodontitis (CP), an inflammatory disease, which is characterized by formation of periodontal pockets, inflammation of pocket walls, absorption of alveolar bone and gradual loosening of teeth, and it is the main cause of tooth loss in adults.[1] Recently, an epidemiological investigation shows that the probability of people suffering from varying degrees of periodontitis is over 80%, and this proportion is even higher among males and smokers.[2] Importantly, there has...

Figure S1. Chronic restraint stress induces depressive-like behaviours in mice. (A) The scheme of CRS exposure experiment. (B) SPT, (C) TST and (D) FST for CRS induced depressive-like behaviours in mice (n = 13, 15 per group, Student's t-test, *P < 0.05     vs. Ctrl group). Error bars represent mean ± SEM. Figure S2. Chronic unpredictable mild stress induces depressive-like behaviours in mice. (A) The scheme of CUMS exposure experiment.