Si-Yong Yin

Graphical Abstract A highly efficient iridium-catalyzed asymmetric C−H alkylation reaction is described. A series of structurally diverse indole-pyrrole and pyrrole-pyrrole N−N atropisomers were obtained in good yields (up to 98 %) with excellent enantioselectivity (up to 99 % ee). This reaction features perfect atom economy, wide substrate scope, and multifunctionalized products allowing diverse transformations.

Transition-metal-catalyzed enantioselective C–H functionalization has become a powerful strategy for the formation of C–C or C–X bonds, enabling the highly asymmetric synthesis of a wide range of enantioenriched compounds. Atropisomers are widely found in natural products and pharmaceutically relevant molecules, and have also found applications as privileged frameworks for chiral ligands and catalysts.