Siang Ing

Background With an increasing trend in the prevalence of maternal autoimmune diseases in pregnancy, there is need for evidence on the association between autoimmune diseases and pregnancy outcomes. Methods This population-based cohort study used data on pregnancies from primary care practices that contributed to the UK Clinical Practice Research Datalink (CPRD) database (Gold and Aurum) between 2000 and 2022, linked to Hospital Episode Statistics (HES).

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This umbrella review aims to summarise the evidence available in the form of systematic reviews studying the adverse pregnancy outcomes in women with autoimmune conditions. This umbrella review has been conducted in accordance with Joanna Briggs Institute (JBI) umbrella review methodology [40], and the PRIOR (Preferred Reporting Items for Overviews of Reviews) checklist was used to report the review [41]. The protocol has been registered to PROSPERO (registration number CRD4202233499).