Siaw Shi Boona on Muck Rack

Siaw Shi Boona

As seen in: American Society for Microbiology (ASM)
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Articles

The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity

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By Paola Massimia, Miranda Thomasa, Siaw Shi Boona, Jayashree Thatte
| American Society for Microbiology (ASM)
The presence of a PDZ binding motif (PBM) in the human papillomavirus (HPV) E6 oncoprotein appears to be a characteristic marker of high oncogenic potential and confers interaction with a number of different cellular PDZ domain-containing substrates. The E6 PBM is also subject to phosphorylation, resulting in inhibition of E6 PDZ binding activity and instead allowing E6 to associate with 14-3-3 proteins. In this study, we analyzed the conditions under which the E6 PBM is phosphorylated.
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