Sibilla Sander on Muck Rack

Sibilla Sander

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MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature Cancer

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By Michael Cangkrama, Josephine Yates, Mai Matsushita, Francesc Castro-Giner, Magdalena K. Sznurkowska, Jörn Dengjel, Valentina Boeva, Nicola Aceto, Sibilla Sander
| Nature Verified
Abstract Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that commonly support cancer development and progression. Here we show that different cancer cells transfer mitochondria to fibroblasts in cocultures and xenograft tumors, thereby inducing protumorigenic CAF features. Transplantation of functional mitochondria from cancer cells induces metabolic alterations in fibroblasts, expression of CAF markers and release of a protumorigenic secretome and matrisome.
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