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Sibo Zhang

Surrey
As seen in: Nature, Wiley Online Library, arXiv, MDPI, ACS Publications, Canadian Journal of Infectious Diseases & Medical Microbiology, Surrey604
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Articles

Nitrifiers Drive Different N 2 O Production Patterns in Tropical River Sediments Click to copy article link Article link copied!

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By Dongdan Yuan, Xiaoyu Cui, Sibo Zhang
| ACS Publications
Abstract Click to copy section linkSection link copied! Since the 20th century, global riverine nitrous oxide (N2O) emissions have increased 4-fold; however, the N2O emissions of tropical rivers are still unclear. Here, we employed a series of techniques (closed chamber, biological inhibitor, 15N–18O double tracer, metagenomic sequencing, and reverse transcription qPCR) to analyze in situ N2O flux, potential N2O production rate, and N2O production mechanism of China’s tropical rivers.
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LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity

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By Yarong Zeng, Jialin Xu, Feng Han, Sibo Zhang, Rong Su, Yufang Li, Renfei Gao, Xiuli Zhang, Lizhi Zhou, Tingting Li, Hai Yu, Qingbing Zheng, Ningshao Xia, Shaowei Li, Ying Gu
| Nature Verified
Abstract The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and activating robust, durable cellular immunity. Here, we engineered a highly translatable vaccine adjuvant delivery system (LNPC) by integrating the Toll-like receptor 9 (TLR9) agonist CpG with the FDA-approved ionizable lipid ALC-0315.
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Combination mRNA Vaccine Adjuvanted with CpG Oligodeoxynucleotides Enhances Protection against Respiratory Virus Infection Click to copy article link Article link copied!

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By Lingyan Cui, Sibo Zhang, Yarong Zeng
| dx.doi.org
The concurrent circulation of respiratory viruses, particularly influenza viruses, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), and RSV (respiratory syncytial virus), poses ongoing population health burdens globally owing to rapid transmission, antigenic drift potential, and seasonal epidemic patterns.
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