Sibo Zhang

Abstract The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and activating robust, durable cellular immunity. Here, we engineered a highly translatable vaccine adjuvant delivery system (LNPC) by integrating the Toll-like receptor 9 (TLR9) agonist CpG with the FDA-approved ionizable lipid ALC-0315.

The concurrent circulation of respiratory viruses, particularly influenza viruses, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), and RSV (respiratory syncytial virus), poses ongoing population health burdens globally owing to rapid transmission, antigenic drift potential, and seasonal epidemic patterns.

1 Introduction Catalysts deactivation by the inevitable water vapor (H2O) in real-working conditions is a widely encountered issue in heterogeneous catalysis process, leading to production shutdown, profit losses, or violation of emission standards[1] H2O will occupy the active sites on the catalysts surface and hard to desorb (the formed surface hydroxyl groups (*OH) exhibit great thermal stability below 250 °C), resulting in irreversible deactivation of catalysts.[2] For decades, intensive...