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Sidika Oztop on Muck Rack

Sidika Oztop

As seen in: Nature
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Articles

Dual-antigen AdV5 vaccines against Crimean-Congo hemorrhagic fever virus induce superior humoral and Th1-biased cellular immunity

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By Alireza Hanifehnezhad, Ece Tavukcuoglu, Gunes Esendagli, Ateş Kara, Hakan Gurdal, Aykut Ozkul, Sidika Oztop, Yigit Tanyeri, Ekimcan Yoyler, Gokcen Gokce Tepeli, Nilay Unal, Asuman Bozkir, M. Taner Karaoglu
| Nature Verified
Abstract Platforms based on adenoviral vectors have proven their efficiency in developing vaccines and therefore can be considered potential candidates for immunization strategies against CCHFV. In this study, four replication-deficient recombinant human adenovirus serotype 5 (AdV5) vectors were engineered to express CCHFV antigens: a dual-antigen NP-P2A-Gc construct and monocistronic constructs for nucleoprotein (NP), glycoprotein complex precursor (GPC), and mature glycoprotein (Gc).
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