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Siduo Li

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Articles

Architecture of the baculovirus nucleocapsid revealed by cryo-EM - Nature Communications

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By Xudong Jia, Yuxuan Huang, Linjun Sun, Harikanth Venkannagari, Matthew Baker, Siduo Li
| Nature Verified
Abstract Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used as a bioinsecticide and a protein expression vector. Despite their importance, very little is known about the structure of most baculovirus proteins. Here, we show a 3.2 Å resolution structure of helical cylindrical body of the AcMNPV nucleocapsid, composed of VP39, as well as 4.3 Å resolution structures of both the head and the base of the nucleocapsid composed of over 100 protein subunits.
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