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Sielke Caestecker

As seen in: Wiley Online Library, BioRxiv
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Articles

The Locus Coeruleus-Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review

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By Sielke Caestecker, Paul Boon, Evelien Carrette, Emma Lescrauwaet
| Wiley Online Library Verified
1 Anatomy The locus coeruleus (LC) is a compact nucleus of noradrenergic neurons situated bilaterally within the pontine brainstem, positioned ventrally to the cerebellum and adjacent to the fourth ventricle. The name locus coeruleus, meaning “blue spot” in Latin, reflects the pigmented appearance of its neuromelanin-containing neurons. Despite its relatively small size, the LC comprises approximately 1500 neurons per nucleus in rodents and between 10,000 to 15,000 neurons in humans.
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Modulation of locus coeruleus neurons and strong release of noradrenaline during acute hippocampal seizures in rats

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By Lars Larsen, Pieter van Mierlo, Sielke Caestecker, Latoya Stevens
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.03.06.531292 Abstract The locus coeruleus (LC), a brainstem nucleus, is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large-scale brain networks.
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