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A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

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By Xuehui He, Sija Landman, Sanavisie Bodyclinic, Hycult Biotech, Irma Joosten
| PLOS
Regulatory T cells (Treg) are important for immune homeostasis and are considered of great interest for immunotherapy. The paucity of Treg numbers requires the need for ex vivo expansion. Although therapeutic Treg flow-sorting is feasible, most centers aiming at Treg-based therapy focus on magnetic bead isolation of CD4+CD25+ Treg using a good manufacturing practice compliant closed system that achieves lower levels of cell purity.
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