Silas Ruhrberg Estévez on Muck Rack

Silas Ruhrberg Estévez

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Articles

Causal inference and digital twins: a roadmap for the future of clinical trials

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By Richard Peck, Eoin F. McKinney, Jim Weatherall, Stuart Bailey, Chris Anagnostopoulos, Pierre Marquet, Anthony Wood, Julianna Piskorz, Christina Günther, Francesca Frau, Ramon Hernandez, Ramón Hernández, Silas Ruhrberg Estévez, Justine Rochon, Harry Amad, Krzysztof Kacprzyk, Rafik Salama, Antoine Pugeat, Mihaela van der Schaar
| Nature Verified
Abstract Clinical trials generate essential evidence on treatment safety and efficacy, but slow timelines, high costs, and limited inclusivity constrain efficiency, generalisability, and clinical impact. Causal inference and digital twins offer complementary tools to define estimands, characterise treatment-effect heterogeneity, assess transportability, and simulate patient trajectories under alternative interventions.
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