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Silke Gillessen Sommer

As seen in: Nature
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Articles

Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression

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By Ping Lai, Lei Liu, Nicolò Pernigoni, Daniele Braga, Martina Troiani, Giuseppe Attanasio, Yuxin Li, Pan Song, Emiliano Pasquini, Tanja Rezzonico Jost, Xiaowen Huang, Martino Maddalena, Simone Mosole, Andrea Rinaldi, Giovanna Pecoraro, Martino Pedrani, Aurora Valdata, Nicolò Bancaro, Alessandra De Giani, Wei Yuan, Lewis Gallagher, Khobe Chandran, Penny Flohr, Pasquale Rescigno, Giuseppe Reitano, Alessandro Morlacco, Fabrizio Dal Moro, Isabella Giacomini, Monica Montopoli, Matteo Brunelli, Ricardo Mestre, Raad Z Gharaibeh, Christian Jobin, Johann De Bono, Andrea Alimonti, Yingxi Du, Luisa Maraccani, Serena Pedron, Silke Gillessen Sommer
| Nature Verified
Abstract Recent studies demonstrate that the gut mycobiota plays a key role in several tumors. However, the contribution of commensal fungi to prostate cancer initiation and progression remains understudied. Here we find that Nakaseomyces glabratus is enriched in fecal, blood and tumor samples of patients with castration-resistant prostate cancer, correlating with patients’ poor overall survival. Oral administration of N.
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