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Silvère Baron on Muck Rack

Silvère Baron

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Articles

Hypusination of the translation factor eIF5A regulates mitochondrial tRNA processing to promote prostate cancer aggressiveness

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By Marc Pujalte-Martin, Anne Vincent, Loïc Trapani, Paraskevi Kousteridou, Amine Belaid, Emilie Thomas, Heather Carr, Frédéric Larbret, Emilie Baudelet, Stéphane Audebert, Didier F. Pisani, Luc Camoin, Mathieu Carlier, Matthieu Durand, Damien Ambrosetti, Yu Chen, Jean-Jacques Diaz, Arnaud Jacquel, Issam Ben-Sahra, Frederic Bost, Michel Kahi, Ludovic Batistic, Victor Tiroille, Joseph Murdaca, Oumayma Benaceur, Marie Irondelle, Christelle Boscagli, Silvère Baron, Nathalie M. Mazure, Pascal Peraldi
| Nature Verified
Abstract Protein synthesis plays a central role in cancer development and progression. eukaryotic initiation factor 5 A (eIF5A), a translation factor activated by hypusination, is implicated in tumorigenesis, however, its mode of action is still unclear. We find that hypusinated eIF5A (eIF5Ahyp) promotes metastasis and tumor growth in prostate cancer (PCa) by supporting mitochondrial metabolism and translation.
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